Endocrine Abstracts

Tissue engineering is a new discipline that capitalizes on the expertise of cell biologists and material scientists. It attempts to create three-dimensional complexes of cells and scaffolds for the purposes of repair, regeneration or replacement of diseased tissue. The tissues and organs are constructed using appropriate cells, genes or other biological building blocks along with bioengineered materials and technologies There is no clear evidence yet as to the most appropriate...

Introduction: We have recently presented data demonstrating total body and regional bone mass relative to body size is reduced in obese children. Adipokines have been shown to play a role in bone metabolism. We hypothesised that 1) increased bone turnover would be associated with reduced bone mass 2) increased serum leptin would be associated with increased osteoclastogenic factors 3) reduced adiponectin woul...

We have previously shown that obese children with prior fracture have a lower bone mass for body size. We further hypothesised that obese children would fail to gain bone mass in relation to body size over a one-year period compared to lean controls.Methodology: Out of 103 children recruited into obese (BMI>98th percentile) and control (BMI<98th percentile) groups at baseline, 66 children aged 6.5–18 years returned at one year. Total body an...

Background: Delayed puberty and related problems with growth and body image in Crohn’s disease (CD) and ulcerative colitis (UC) have rarely been quantified.Methods: A longitudinal prospective observational study of children with IBD who had anthropometric and puberty data at 0 and 6 months. Of 50 recruited, there were 15 boys (CDM) and 20 girls (CDF) with CD and ten boys (UCM) and five girls (UCF) with UC. The four groups had a median age at 0 month...

Background: Puberty is understood to be commonly effected in adolescents with Crohn’s Disease (CD) and ulcerative colitis (UC). However, the extent of this effect and related problems with growth, have rarely been quantified.Objective: To determine the impact of CD and UC on pubertal growth.Methods: Retrospective study of 148 children with IBD (casenotes available, 135) who fulfilled the criteria for describing growth spurt pa...

Endocrine-Related Cancer, 2021, 28(12): 757-772 (DOI: https://doi.org/10.1530/ERC-21-0211)...